Proliferative multifocal leukoplakia better name that proliferative verrucous leukoplakia

In this letter I propose the name "Proliferative Multifocal Leukoplakia" with the goal of reducing under-diagnosis of this disease, improve the early diagnosis, try to make an early therapy and control, and prevent its malignant transformation

Conservative Surgical Management of Stage I Bisphosphonate-Related Osteonecrosis of the Jaw

Purpose. To report the efficacy of conservative surgical treatment for stage I bisphosphonate-related osteonecrosis of the jaw (BRONJ). Materials and Methods. This study reports the clinical outcomes of 63 patients treated for BRONJ stage I (according to Ruggiero's staging system) at the Oral Pathology and Laser-Assisted Surgery Unit of the University of Parma between January 2004 and January 2011. Surgical interventions were performed, under local analgesia, in patients unresponsive for a period of six months to noninvasive treatments such as cycles of local or systemic antibacterial therapy combined or not to low level laser therapy, ozone therapy, or Hyperbaric Oxygen Therapy. All interventions were performed after the consultation of oncologist or physician. Results. In our experience, conservative surgical treatment is associated with the highest number of BRONJ healed sites in stage I disease. Complete healing was observed in 92.6% of sites surgically treated. Conclusions. This study confirms that treatment of patients affected by minimal bone exposition, (stage I of BRONJ), through conservative surgical strategies, possibly with laser, may result in a high control of the disease in the long term

Genome-Wide Association Study Identifies First Locus Associated with Susceptibility to Cerebral Venous Thrombosis

Objective Cerebral venous thrombosis (CVT) is an uncommon form of stroke affecting mostly young individuals. Although genetic factors are thought to play a role in this cerebrovascular condition, its genetic etiology is not well understood. Methods A genome-wide association study was performed to identify genetic variants influencing susceptibility to CVT. A 2-stage genome-wide study was undertaken in 882 Europeans diagnosed with CVT and 1,205 ethnicity-matched control subjects divided into discovery and independent replication datasets. Results In the overall case-control cohort, we identified highly significant associations with 37 single nucleotide polymorphisms (SNPs) within the 9q34.2 region. The strongest association was with rs8176645 (combined p = 9.15 x 10(-24); odds ratio [OR] = 2.01, 95% confidence interval [CI] = 1.76-2.31). The discovery set findings were validated across an independent European cohort. Genetic risk score for this 9q34.2 region increases CVT risk by a pooled estimate OR = 2.65 (95% CI = 2.21-3.20, p = 2.00 x 10(-16)). SNPs within this region were in strong linkage disequilibrium (LD) with coding regions of the ABO gene. The ABO blood group was determined using allele combination of SNPs rs8176746 and rs8176645. Blood groups A, B, or AB, were at 2.85 times (95% CI = 2.32-3.52, p = 2.00 x 10(-16)) increased risk of CVT compared with individuals with blood group O. Interpretation We present the first chromosomal region to robustly associate with a genetic susceptibility to CVT. This region more than doubles the likelihood of CVT, a risk greater than any previously identified thrombophilia genetic risk marker. That the identified variant is in strong LD with the coding region of the ABO gene with differences in blood group prevalence provides important new insights into the pathophysiology of CVT. ANN NEUROL 2021Peer reviewe

Potential Non-Invasive Biomarkers for Early Diagnosis of Oral Squamous Cell Carcinoma

This study aimed to investigate the role of a panel of salivary cytokines as biomarkers for early detection oral squamous cell carcinoma (OSCC), comparing their levels among healthy individuals, patients with oral leukoplakia (OL), and malignant lesions. Cytokine profiling analysis performed in a minimally invasive sample was correlated with clinicopathological variables in our patient cohorts. Unstimulated saliva was obtained from subjects with OSCC at early (n = 33) and advanced (n = 33) disease, OL with homogeneous (n = 33) and proliferative verrucous (n = 33) clinical presentations, and healthy controls (n = 25). Salivary IL-1α, IL-6, IL-8, IP-10, MCP-1, TNF-α, HCC-1, and PF-4 levels were analyzed by a sensitive bead-based multiplex immunoassay. Mean levels of IL-6, IL-8, TNF-α, HCC-1, MCP-1, and PF-4 differed significantly between OSCC, OL, and control saliva (p < 0.05). We found notably higher IL-6 and TNF-α in advanced compared to early OSCC stages. The area under the curve (AUC) for OSCC vs. control was greater than 0.8 for IL-6, IL-8, TNF-α, and HCC-1, and greater than 0.7 for PF-4. The presence of neck metastases (NM) was associated with increased IL-6 and TNF-α levels. Our findings suggest that salivary IL-6, IL-8, TNF-α, HCC-1, and PF-4 may discriminate between OSCC, OL, and healthy controls. IL-6 and TNF-α may indicate OSCC progression, being distinctive in the presence of NM

Crosslinked plastic scintillators: A new detection system for radioactivity measurement in organic and aggressive media

The measurement of radioactive solutions containing organic or aggressive media may cause stability problems in liquid and plastic scintillation (PS) techniques. In the case of PS, this can be overcome by adding a crosslinker to the polymer structure. The objectives of this study are to synthesise a suitable crosslinked plastic scintillator (C-PS) for radioactivity determination in organic and aggressive media. The results indicated that an increase in the crosslinker content reduces the detection efficiency and a more flexible crosslinker yields higher detection efficiency. For the polymer composition studied, 2,5-diphenyloxazole (PPO) is the most adequate fluorescent solute and an increase in its concentration causes little change in the detection efficiency. The inclusion of a secondary fluorescent solute 1,4-bis-2-(5-phenyloxazolyl) benzene (POPOP) improves the C-PS radiometrical characteristics. For the final composition chosen, the synthesis of the C-PS exhibits good reproducibility with elevated yield. The obtained C-PS also displays high stability in different organic (toluene, hydrotreated vegetable oil (HVO) and methanol) and aggressive media (hydrochloric acid, nitric acid and hydrogen peroxide). Finally, the C-PS exhibits high detection efficiency both in water and in aggressive media and can also be applied in organic media showing similar or even higher detection efficiency values. (C) 2014 Elsevier B.V. All rights reserved

Adverse Reactions to Anticancer Drugs in the Oral Cavity

The development, testing, and adoption into clinical practice of anticancer medications have revolutionized cancer care over the past decades. A better understanding of the biology of cancer has translated into development of novel systemic agents, as well a more effective use of older chemotherapy agents. As a consequence, cancer mortality continues to decrease. However, greater cure and disease control rates come at a price of an increased risk of adverse effects, which often affects the mouth and related structures including the oral mucosa, salivary glands, jawbones, and cranial nerves. Oral mucositis, hyposalivation, dysgeusia, and osteonecrosis of the jaw (ONJ) are some examples of the potential adverse effects of anticancer therapies to the oral cavity, which affect an increasing number of individuals living with cancer and cancer survivors and can lead to persistent discomfort, pain, dysfunction, and a notable reduction in the quality of life. Management of these oral adverse effects can be challenging, as it typically requires a multidisciplinary approach and a close collaboration between the cancer team and oral health care providers, both in primary care and in the specialist setting. This special issue provides a useful update of some of the most significant adverse reactions to anticancer drugs in the oral cavity, with a view to inform clinical practice and inspire further research. Multitargeted tyrosine kinase inhibitors including sunitinib, sorafenib, axitinib, and cabozantinib are increasingly used in the cancer setting, and C. Arena et al. provide in this special issue a useful systematic review on oral mucositis associated with these agents. Similarly, K. Pimolbutr et al. report on the development of ONJ associated with antiangiogenic agents in the subset of antiresorptive-na\uefve patients. Prevention of toxicity is crucial in individuals due to commence and in those who have been using antiresorptive medications, and O. Di Fede et al. discuss the main strategies to reduce the risk ONJ in this patient population. The surgical treatment of medication-related ONJ is a relatively new field of research, as this condition has been historically managed conservatively with a focus on pain management and resolution of infection. In this special issue, R. Mauceri et al. report on the use of Er,Cr:YSGG laser and platelet-rich plasma in the surgical treatment of ONJ, whereas R. Sacco et al. provide a systematic review of the efficacy of microsurgical reconstruction of the jaws using vascularized free flap in patients with medication-related ONJ. We hope that the readers of BioMed Research International will find this special issue interesting and informative

Biomaterials coated by dental pulp cells as substrate for neural stem cell differentiation

[EN] This study is focused on the development of an in vitro hybrid system, consisting in a polymeric biomaterial covered by a dental pulp cellular stroma that acts as a scaffold offering a neurotrophic support for the subsequent survival and differentiation of neural stem Cells. In the first place, the behavior of dental pulp stroma on the polymeric biomaterial based on ethyl acrylate and hydroxy ethyl acrylate copolymer was studied. For this purpose, cells from normal human third molars were grown onto 0.5-mm-diameter biomaterial discs. After cell culture, quantification of neurotrophic factors generated by the stromal cells was performed by means of an ELISA assay. In the second place, survival and differentiation of adult murine neural stem cells on the polymeric biomaterials covered by dental pulp stromal cells was studied. The results show the capacity of dental pulp cells to uniformly coat the majority of the material's surface and to secrete neurotrophic factors that become crucial for a subsequent differentiation of neural stem cells. The use of stromal cells cultured on scaffolding biomaterials provides neurotrophic pumps that may suggest new criteria for the design of cell therapy experiments in animal models to assist the repair of lesions in Central Nervous System.Contract grant sponsors: Programa de ayudas a la Investigacion cientifica Raman Areces; convenio de colaboracion entre el Instituto de Salud Carlos III, la Conselleria de Sanidad de la Generalitat Valenciana y la Fundacion de la Comunidad Valenciana Centro de Investigacion Principe Felipe para la investigacion basica y traslacional en medicina regenerativeSoria, JM.; Sancho-Tello, M.; Garcia Esparza, MA.; Mirabet, V.; Bagan, JV.; Monleón Pradas, M.; Carda, C. (2011). Biomaterials coated by dental pulp cells as substrate for neural stem cell differentiation. Journal of Biomedical Materials Research Part A. 97 A(1):85-92. https://doi.org/10.1002/jbm.a.33032S859297 A